This newsletter discusses the health and social impacts of synthetic cannabinoids, or ‘Spice’. These substances are linked to severe withdrawal symptoms and negative social effects, particularly among vulnerable groups. Despite their low overall prevalence, usage is higher in certain subpopulations due to their perceived legality and affordability. The risks are amplified by common polydrug use among users, highlighting the need for increased awareness and support.
Since the discovery of THC, the medical industry has been interested in studying the interactions between cannabinoids and the human endocannabinoid system (ECS). Synthetic cannabinoids (SCBs) have been developed to mimic the effects of natural cannabinoids, with thousands of compounds created. These chemicals have different structures and a higher affinity for ECS receptors, making them more potent than natural cannabinoids. They have been used in pharmacological studies and show potential for treating various medical conditions. However, they also have drawbacks such as unpredictable side effects and a higher risk for abuse.
Cannabimimetic compounds, including cannabinoids, terpenes, and non-cannabinoid constituents, have garnered considerable interest for their interactions with the human endocannabinoid system (ECS). While THC and CBD are widely studied, numerous non-cannabis plants have been found to produce cannabimimetic components that stimulate or modulate the ECS. These compounds can bind to cannabinoid receptors or influence ECS-related enzymes. Such interactions impact physiological processes like neurotransmission, sleep, appetite, mood, and immune response. Alkaloids, terpenes, and other compounds in common herbs and spices exhibit cannabimimetic properties. Understanding and harnessing these compounds hold promise for therapeutic interventions. In this newsletter, we will provide an overview of Cannabis-like compounds beyond the Cannabis genus, highlighting their potential and importance in expanding therapeutic research and drug development.
Discover the hidden truth behind the booming cannabis industry. As the number of cannabis consumers soars, it’s time to shed light on the environmental consequences of this popular plant. Delve into the fascinating world of cannabis cultivation and its complex relationship with our planet. From water scarcity concerns to air pollution and energy consumption, we unravel the highs and lows of this budding industry. Uncover the secrets of sustainable practices, carbon sequestration, and the remarkable potential of hemp. Join us in finding a balance between reaping the benefits and protecting our environment.