Cannabimimetic compounds, including cannabinoids, terpenes, and non-cannabinoid constituents, have garnered considerable interest for their interactions with the human endocannabinoid system (ECS). While THC and CBD are widely studied, numerous non-cannabis plants have been found to produce cannabimimetic components that stimulate or modulate the ECS. These compounds can bind to cannabinoid receptors or influence ECS-related enzymes. Such interactions impact physiological processes like neurotransmission, sleep, appetite, mood, and immune response. Alkaloids, terpenes, and other compounds in common herbs and spices exhibit cannabimimetic properties. Understanding and harnessing these compounds hold promise for therapeutic interventions. In this newsletter, we will provide an overview of Cannabis-like compounds beyond the Cannabis genus, highlighting their potential and importance in expanding therapeutic research and drug development.