CBD and THC are the two most significant cannabinoids found in cannabis. Raphael Mechoulam discovered the structure of THC in 1964 and found it to be psychoactive. The discovery of THC led to the exploration of the endocannabinoid system (ECS) which is made up of chemical compounds that bind to cannabinoid receptors (CBRs) found in the nervous system. The ECS influences a wide variety of processes, including motor learning, appetite, and pain sensation. THC is thought to bind to CB1 receptors in the brain and regulate hunger by affecting the production of endocannabinoids.